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While glucose is targeted in some cancer treatments, healthy cells also use it as fuel, and so a blanket approach of glucose deprivation can hurt them , too.
Hence the search for a selective means of robbing cancer cells of their precious nutrient. Leveraging the fact that some cancers are more sensitive to glucose denial than others, the team isolated a line of cancer cells that succumbed to glucose starvation within just 10 hours.
Switching focus to their more robust counterparts, they found cells able to resist the enforced famine maintained higher levels of intracellular glucose.
The researchers showed, for the first time, those tiny amounts of glucose had a signalling function which prevented calcium influx and a cascade of molecular changes culminating in cell death.
Both types of cells were then subjected to a two-pronged attack with STF, a compound that inhibits glucose transport into cells, and thapsigargin, which ramps up the level of calcium in cells.
Cells that had that extra glucose in the tank shrugged off the assault, while those that held more meagre reserves went to the wall. Picking off those relatively depleted tumour cells could, the researchers say, be a winning strategy.
Sugar is also fingered as a cancer co-conspirator in separate research published in the Journal of Biological Chemistry.
A team led by Hans Wandall, from the Department of Cellular and Molecular Medicine at the University of Copenhagen, has found that an enzyme responsible for attaching sugar to proteins in colon cells is overactive in gut cancer.
The findings suggest that when the enzyme, called GalNAc-T6, attaches sugars called glycans to bowel cells, it promotes cell adhesion and the formation of tubular structures characteristic of bowel cancer.
That process, say the researchers, helps refine another target for cancer treatment. Australian experts have stressed that healthy cells are also starved of sugar, unhelpful for a body fighting disease, and that wily cancer cells will just break down fats to make sugar anyway.
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Crazy Credits. Alternate Versions. Rate This. Damon Gameau embarks on an experiment to document the effects of a high sugar diet on a healthy body.
Director: Damon Gameau. Writer: Damon Gameau. See Showtimes. Added to Watchlist. From metacritic. High School Icons, Then and Now.
Use the HTML below. You must be a registered user to use the IMDb rating plugin. Edit Cast Credited cast: Damon Gameau Self Hugh Jackman Self Rest of cast listed alphabetically: Milla Bakaitis Sugar Devil Richard Davies Sugar Shopper Skylar Delphinus Sugar Dancer Benjamin Hancock Sugar Dancer Zelia Kitoko Self Jessica Marais Self Brenton Thwaites Edit Storyline One man's journey to discover the bitter truth about sugar.
Taglines: 3 years ago Damon Gameau gave up sugar. But for the next 60 days, he'll eat "healthy" again. He'll risk his well-being, and his waist line, for his family's future.
Genres: Documentary. Edit Did You Know? Trivia One of the inspirations for the film happened 10 years earlier when Australian Aboriginal actor David Gulpilil invited Damon Gameau , his co-star from The Tracker , to visit him in his native land, the Arnhem area of Australia's Northern Territory.
Gameau was immediately struck by how much Western culture and food had been assimilated into the Aboriginal lands. Seeing mothers feed their babies Coca-Cola through their baby bottles disturbed him greatly.
Was this review helpful to you? Yes No Report this. Add the first question. Country: Australia.